A Brief History of Delaware Valley Mass Spec Discussion Group
The Delaware Valley Mass Spectrometry Discussion Group (DVMSDG) serves a diverse group of scientists from both academia and industry. DVMSDG is hosted by the Department of Chemistry at Villanova University, just thirty minutes outside of downtown Philadelphia. Attendance at the monthly meetings is typically 20-35 scientists and students, with some meetings and events drawing in excess of 100 people.
DVMSDG was created to meet the interests of a variety of scientists with diverse backgrounds. Due to a large number of local scientists in the biotechnology and pharmaceutical industries, many of the seminars are weighted towards these areas. However, we attempt a balanced program between theory and applications, while also trying to provide perspective on the history of mass spectrometry for the younger generation of mass spectrometrists studying at local universities.
Discovery of two isotopes of neon: neon-20 and neon-22, by J.J. Thompson.
Chair Eugene Ciccimaro, Bristol Myers Squibb
Chair Elect Rachel Ciotti, Agilent Technologies
Secretary Brett Peterson, MOBILion Systems
Past Chair Joe Cannon, Bristol Myers Squibb
Treasurer Qiu Xi, Agilent Technologies
Awards Chair Steven LaMonaca, DuPont
Webmaster William Shen, Waters Corporation
Group Advisor Harsha Gunawardena, Janssen R&D, J&J
Due to COVID-19 concerns, all events will be via Zoom. In-person meetings coming up soon!
Infrared (IR) spectra of gas-phase ions provide detailed fingerprints that are sensitive to the minutest differences in molecular structure and hence can easily distinguish between isomeric species. Although practiced in many academic research laboratories, gas-phase IR spectroscopy has not yet found its way into the world of analytical mass spectrometry. There are at least two obvious reasons for this: (1) the addition of a spectroscopic dimension to an analytical measurement has typically taken tens of minutes for each species, making it poorly suited to high-throughput analysis; and (2) the complex, expensive lasers required have made spectroscopic measurements impractical for biomedical research.
We have overcome these problems in an approach that combines ultrahighresolution SLIM-based ion mobility, cryogenic IR spectroscopy, and mass in a single instrument. By increasing sensitivity and implementing a multiplexing approach to spectral measurement, we can measure an IR fingerprint spectrum of a molecule in as little as 10 seconds. Moreover, we do this using a simple, user-friendly, fiber-pumped IR laser no larger than a shoebox.
After demonstrating the capabilities of our technique, this talk will focus on its application in distinguishing isomeric glycans and glycan-related metabolites. We also have developed schemes to generate IR reference spectra starting from a relatively small number of simple, readily available standards from which we can grow a database for more complex species.
The goal of HPLC 2022 is to bring together scientists at all professional levels involved with all aspects of liquid-phase separations from fundamental research to practice, to provide a dynamic program with cutting-edge presentations and engaging scientific sessions, and to offer wide opportunities for training, networking, and informal discussion. Scientists and researchers will present the latest trends and issues in areas such as column technologies, 3D-printing, multidimensional LC, capillary LC, SFC, micro-and nanofluidics, omics, mass spectrometry, sample preparation, theory of the chromatographic separation processes, machine learning, and artificial intelligence, as well as a myriad of other topics related to liquid-phase separations and analyses.
The Delaware Valley Mass Spectrometry Discussion Group (DVMSDG) is sponsoring two travel awards for students who plan to present at the 67th American Society for Mass Spectrometry (ASMS) Conference, June 2nd - 6th, 2019 in Atlanta, GA. Applicants must be enrolled full-time in either a graduate or undergraduate program at a college/university in the greater Philadelphia/Delaware Valley region.
Interested applicants should submit the following information:
Applications should be submitted electronically in Word or PDF format by May 3rd , 2019 to: Steven.Mark.LaMonaca@dupont.com
Applications will be judged by DVMSDG Board, and the winners will be announced at our annual Vendors’ Night meeting on May 7th, 2019.
Further information about DVMSDG can be found at our website: http://dvmsdg.org
Please contact me if you have any questions regarding this award or the application process.
Sincerely,
Steven M. LaMonaca
Awards Chair, DVMSDG
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Tracie Brambos
phone: 585-492-1068
e-mail: tracie@gentechscientific.com
Allan Xu
phone: 215-699-8885
e-mail: axu@keystonebioanalytical.com
Carla Marshall-Waggett
phone: 781-305-9822
e-mail: Carla.marshall-waggett@newobjective.com
George Verzi
phone: 610-621-3981
e-mail:NeMassSpecs@gmail.com
Chris Hogan; Karen Luo
phone: 267-377-9571
e-mail: Chris_Hogan@waters.com; Karen_Luo@waters.com
Driving Directions to Mendel Hall
From the East: Take the Pennsylvania Turnpike (276) Westbound to Exit 20 (Mid-County Interchange) I-476 South/Chester. Follow I-476 South to Exit 13 (Villanova/St. Davids). At the bottom of ramp turn right onto Route 30 East, also known as Lancaster Avenue. Proceed east on Route 30 (Lancaster Avenue). To reach the Ithan Ave. entrance, turn left at Ithan Ave. to the guard shack on left. Proceed to the parking lot behind Mendel Hall.
From the West: Take the Pennsylvania Turnpike (76) to Exit 326 - Valley Forge (formerly Exit 24). Take I-76 (Schuylkill Expressway) to Exit 331A(I-476 South/Chester) to Exit 13 (US 30 St. Davids/Villanova) to Route 30 East, also known as Lancaster Avenue. Proceed east on Route 30 (Lancaster Avenue). To reach the Ithan Ave. entrance, turn left at Ithan Ave. to the guard shack on left. Proceed to the parking lot behind Mendel Hall.
From the South: Take I-95 North to Exit 7 (I-476 (Blue Route) North-Plymouth Meeting). Take I-476 (Blue Route) North to Exit 13 (Villanova/St. Davids) Lancaster Avenue) to Route 30 East, also known as Lancaster Avenue. Proceed east on Route 30 (Lancaster Avenue). To reach the Ithan Ave. entrance, turn left at Ithan Ave. to the guard shack on left. Proceed to the parking lot behind Mendel Hall.
Using SEPTA
Via Regional Rail: Take appropriate train from your location to 30th Street Station in Center City Philadelphia. Take SEPTA's Regional Rail Line, R5 (Paoli Local) to Villanova Station - directly on campus. When you leave the train, take the pedestrian tunnel under the tracks and walk straight to Mendel Science Center.